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Pharmaceutical Analysis
book

Pharmaceutical Analysis

by P. D. Chaithanya Sudha
July 2012
Intermediate to advanced content levelIntermediate to advanced
758 pages
17h 12m
English
Pearson India
Content preview from Pharmaceutical Analysis

Chapter 2

Non-aqueous Titrations

INTRODUCTION

Boyle first recorded the insolubility of the water soluble salts in alcohol. In 1912 Folin and Flanders titrated the acidic substances by using the non-aqueous solvents such as benzene, chloroform and chloroform-methanol mixture. Conant and Hall in 1927 described the behaviour of bases in glacial acetic acid. Lowitz first prepared the moisture-free solvents (non-aqueous solvents). Vorlander first proposed the non-aqueous titration method that is titration of aniline with the HCl in non-aqueous solvent, that is, benzene. The steps involved in the non-aqueous titrimetric method are proposed by the Tomicek. Fritz first used this method to distinguish the aromatic and aliphatic amines by using the perchloric ...

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Publisher Resources

ISBN: 9789332515659