Pharmaceutical Analysis

Chapter 6

Gas Chromatography

INTRODUCTION

Gas Chromatography (GC) was invented by A. J. P. Martin. Martin and Synge recommended that the liquid mobile phase used in liquid chromatography could be replaced by a suitable gas. Fritz Prior first developed the solid-state gas chromatography. A more sophisticated form of the gas chromatography was constructed by James and Martin and described by James in 1955.

PRINCIPLE AND THEORY

The GC is the chromatographic technique where the sample is vapourised by the injection into the heated column by a inert gaseous mobile phase. In this technique, the mobile phase is the gas and the stationary phase is the solid or liquid. If the stationary phase is liquid then it is called as the gas-solid chromatography. ...