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Pharmaceutical Analysis
book

Pharmaceutical Analysis

by P. D. Chaithanya Sudha
July 2012
Intermediate to advanced content levelIntermediate to advanced
758 pages
17h 12m
English
Pearson India
Content preview from Pharmaceutical Analysis

Chapter 1

3-Methyl-2-Benzothiazolinone Hydrazone (MBTH)

INTRODUCTION

3-Methyl-2-benzothiazolinone hydrazone was first synthesised by Besthorn in 1910. Huning and Fritsch has described the oxidative coupling of this reagent with phernds, aromaticamines, heterocyclic-based compounds containing active methylenegroup to form highly coloured products in 1957. In 1961, Saltlicki et al. introduced MHTH into analytical chemistry.

STRUCTURE

 

3-Methyl benzothiazolinone hydrazone

 

3-Methyl benzothiazolinone hydrazone

MECHANISM OF ACTION

Under experimental conditions, MBTH loses two electrons and one proton on oxidation forming the electrophilic intermediate which is an active coupling spectres. ...

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Publisher Resources

ISBN: 9789332515659