July 2012
Intermediate to advanced
758 pages
17h 12m
English
Content preview from Pharmaceutical Analysis
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Chapter 1
3-Methyl-2-Benzothiazolinone Hydrazone (MBTH)
INTRODUCTION
3-Methyl-2-benzothiazolinone hydrazone was first synthesised by Besthorn in 1910. Huning and Fritsch has described the oxidative coupling of this reagent with phernds, aromaticamines, heterocyclic-based compounds containing active methylenegroup to form highly coloured products in 1957. In 1961, Saltlicki et al. introduced MHTH into analytical chemistry.
STRUCTURE
3-Methyl benzothiazolinone hydrazone
MECHANISM OF ACTION
Under experimental conditions, MBTH loses two electrons and one proton on oxidation forming the electrophilic intermediate which is an active coupling spectres. ...