Pharmaceutical Analysis

Chapter 3

Analysis of Carboxylic Acids

INTRODUCTION

The most of the pharmaceutical agents contain the carboxylic acids. The carboxylic acid containing drugs are Salicylic acid derivatives used as antipyretics, Nicotinic acid, para-amino benzaldehyde, etc.

Based on the importance of these drugs, the analytical methods are proposed. They are as follows:

• IR method: This method is mainly based on the absorption of the IR radiation by the sample which is because of the stretching vibrations of the C=O bond which is measured at the 5.65–5.80 μm.
• UV method: This method is mainly based on the determination of the UV radiation absorption by the sample which under goes transition. This is carried by dissolving the sample in the appropriate solvent and ...