Chapter 14: Basic Mixture Designs for Materials Experiments

Overview.. 321

The Problem: Precipitants in a Liquid Drug Solution. 321

Design of Mixture Experiments. 322

Ternary Plots for Model Diagnosis. 326

Analysis of Mixture Design Results. 328

Model Profiler 331

The Practical Application of Profiler Optimization. 335

Practical Conclusions. 338

Exercises. 339



A simple materials experiment was executed in chapter 9 that involved the study of materials variables as independent factors and that used a slack variable to maintain a fixed amount of total materials. Such designs are easy to design, analyze, and interpret. However, the chance for error is increased because you can never know whether the changes are due to the model or ...

Get Pharmaceutical Quality by Design Using JMP now with the O’Reilly learning platform.

O’Reilly members experience books, live events, courses curated by job role, and more from O’Reilly and nearly 200 top publishers.