8.3. Assessing Dose Linearity
As discussed in the introduction, when an oral tablet is taken it will be absorbed, distributed, metabolized and eliminated. Imagine that the body is made up of many different compartments. The drug amount that enters circulation is then both simultaneously distributed into and eliminated from these compartments. Typically, a drug is eliminated from the body through urine or feces. In order to facilitate this process, the liver often metabolizes the compound to a chemical form that is more readily eliminated. If all of the eliminations from one compartment to another are proportional to the concentration of the compound in the compartment, the drug has dose linearity. Dose linearity implies that the elimination ...
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