Pharmaceutical Statistics Using SAS

12.2. Case Studies

We will present three case studies which will be used throughout this chapter.

EXAMPLE: Exercise trial

In this heart failure study, the primary efficacy endpoint is based upon the ability to do physical exercise. This ability is measured in the number of seconds a subject is able to ride an exercise bike. The data collected in the study are included in the EXERCISE data set that can be found on the book's companion Web site. There are 25 subjects assigned to placebo (GROUP=0) and 25 to treatment (GROUP=1). The treatment consisted of the administration of ACE inhibitors. Four measurements were taken at monthly intervals (TIME variable). The Y variable represents the outcome scores transformed to normality.

All 50 subjects are ...