Pharmaceutical Statistics Using SAS

2.1. Introduction

Drug discovery teams are often faced with data for which the samples have been categorized into two or more groups. For example, early in the drug discovery process, high throughput screening is used to identify compounds' activity status against a specificbiological target. At a subsequent stage of discovery, screens are used to measure compounds' solubility, permeability, and toxicity status. In other areas of drug discovery, information from animal models on disease classification, survival status, and occurrenceof adverse events is obtained and scrutinized. Based on these categorizations, teams must decide which compounds to pursue for further development.

In addition to the categorical response, discovery data often contains ...