5.5. Statistical Analysis of a One-Factor Design with Repeated Measures
In this section, we discuss the methods for analyzing the body weight data from rodent and large animal toxicology studies. Since body weights of each animal are collected throughout the study, they are repeated measures data. The repeated measures analysis is a logical choice for large animal toxicology studies (Thakur, 2000) and rodent toxicology studies (Hoffman, et al., 2002) with data that are repeated in nature. For a typical four-treatment-group two-year carcinogenicity study, there could be as many as 60 rats per sex for each treatment group, each receiving a $0$ (vehicle), low, mid, or high dose of a compound daily for the entire two years. The body weights of each ...
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