O'Reilly logo

Process Control: Modeling, Design, and Simulation by B. Wayne Bequette

Stay ahead with the world's most comprehensive technology and business learning platform.

With Safari, you learn the way you learn best. Get unlimited access to videos, live online training, learning paths, books, tutorials, and more.

Start Free Trial

No credit card required

M12.3. Intravenous Delivery of Anesthetic Drugs

Traditionally, most anesthetics have been vapor-phase, such as isoflurane. In recent years there has been a move toward the intravenous (IV) delivery of drugs for anesthesia. One of the more popular IV anesthetics is propofol. For a particular population of subjects, the following kinetic values have been determined: k10 = 0.152, k12 = 0.207, k13 = 0.040, k21 = 0.092, and k31 = 0.0048, all with units of min-1. Also, assume that the volume of the blood plasma compartment is V1 = 12 liters.

  1. What is the required steady-state propofol infusion rate to maintain a desired blood concentration of 2 μg/ml?

  2. Develop the state space model, based on Equations (M12.2) and (M12.3 or M12.4), assuming that the plasma ...

With Safari, you learn the way you learn best. Get unlimited access to videos, live online training, learning paths, books, interactive tutorials, and more.

Start Free Trial

No credit card required