Basic principles of human embryonic stem cells
D. Ilic, D. Stevenson, H. Patel and P. Braude, King’s College London School of Medicine UK
Despite increasing interest in other stem cell types including induced pluripotent stem cells (iPSC), human embryonic stem cells (hESC) remain the gold standard pluripotent cell type. Clinical use of hESC is now being explored in a number of phase I clinical trials, including safety trials for spinal cord injury (Geron, started October 2010) and macular degeneration (ACT, started July 2011). At the same time, several hESC-based models for preclinical drug testing became commercially available. Here we are providing a brief overview of the biological properties of hESC, a historical overview ...