Bone marrow mesenchymal progenitor and stem cell biology and therapy
T. Lee, University at Buffalo, USA
Human mesenchymal stem cells (MSC) can be readily expanded from a small amount of bone marrow aspirate, and are currently being used in clinical trials for treating many diseases. Although MSC possess prominent multi-lineage differentiation potential, this stem cell feature appears to contribute little to the observed therapeutic benefits. Instead, the ability of MSC to produce a broad spectrum of growth factors and cytokines plays a critical role in the revitalization and healing of host tissue. However, the source of MSC, the mechanism of stem cell action, treatment modality, and influence of host aging remain to be investigated, ...