Lung progenitor and stem cell biology and therapy
I.P. Neuringer, Massachusetts General Hospital USA
Abstract:
This chapter outlines the diverse populations of endogenous and circulating lung stem cells which play a role in lung homeostasis and responses to lung injury. The role of lung stem cells in the pathobiology of such lung diseases as COPD, lung cancer, ARDS, pulmonary fibrosis, pulmonary hypertension, and cystic fibrosis is discussed, as well as the potential benefit of lung stem cell therapy. Significant advances in the field include transgenic mouse models to test mechanisms of lung stem cell function, and bioengineered lung tissue.
Key words
basal cell
Clara cell
bronchioalveolar stem cell (BASC)
type I and type II alveolar ...
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