Trace Elements and
Human Health
Mehrdad Gholami
* and Hojatollah Yamini
Elements which occur in the organism in very small quantities, less than
0.01 percent, are generally referred to as trace elements (Oliver 1997). Trace
elements play very important roles in nutrition and health. There have been
several reports pointing to the correlation of diseases linked to mineral
defi ciency. For instance, in the 1930s, occurrence of goiter in the goiter belt
of the United States was associated with insuffi cient iodine in plants and soil
(Zimmermann 2011, Anderson et al. 2010, White and Zasoski 1999). Another
example is the Keshan disease, widespread and endemic in some areas of
China, leading to myocardial fi brosis and necrosis. In the 1970s, selenium
defi ciency was discovered to be one of the main determinant factors of
Keshan Disease through two main observations: fi rstly, crops in the area had
an extremely low selenium content, and secondly administration of selenium
before establishment of the disease had a salutary effect on the health of
the patients (Hurst 2011, Burk and Lane 1983, Tan et al. 2002). On the other
Department of Chemistry, Islamic Azad University, Marvdasht Branch, Marvdasht, Iran.
Email: m.gholami@miau.ac.ir
Department of English, Islamic Azad University, Marvdasht Branch, Marvdasht, Iran.
Email: arashyamini@yahoo.com
*Corresponding author
546 Speciation Studies in Soil, Sediment and Environmental Samples
hand, for many decades, human beings have contaminated the environment
by dumping and emission of trace element species because they thought
this would be harmless due to eventual dilution of contaminations in the
environment. This was a naive idea which overlooked the transformations of
trace element species in the biosphere which can totally alter their behavior.
Trace element species without any doubt affect the food chain. However
this was a grave mistake with lethal consequences since human beings
are contaminated by various harmful trace element species. These species
accumulate in the fl ora and fauna and their concentrations increasing at
accelerating rate and ascending order in the food chain as a result of a process
known as bioaccumulation. As an example, in 1956, the subtle and serious
consequences of methyl mercury exposure became evident in Minamata,
Japan. Minamata Bay was contaminated with mercury and methyl mercury
from a factory manufacturing chemical acetaldehyde. Mercury was used
in the manufacturing process, both mercury and methyl mercury being
discharged into Minamata Bay. The fi sh in the bay accumulated increasing
amounts of methyl mercury, which was subsequently passed to the fi sh-
consuming residents of the area. This was one of the fi rst modern lessons
of the consequences of the bioaccumulation of methyl mercury (Chan
2011, Walker 2010, Gilbert 2005). Another tragic incident in Iraq clearly
documented the fatal effects of maternal methyl mercury exposure. During
the winter of 1971, some 73,000 tons of wheat and 22,000 tons of barley
were imported into Iraq. This grain, pink-colored mercury-coated seed
grain, intended for planting, was treated with various organic mercurials. A
severe drought in Iraq resulted in a loss of seed grain as people struggling
with malnutrition consumed the seed grains. Unfortunately, the illiterate
local population could not realize the English writings and warnings on
the seed bags nor recognize the pink seeds as hazardous. Bread made from
these seeds was pink, tasty, but toxic, particularly for the growing children,
resulting in the hospitalization of some 6530 and death of 459 people at the
time of the study (Bakir et al. 1973, Syversen and Kaur 2012).
Trace elements can be categorized as i) essential elements with
physiological relevance (microelements or micronutrients), ii) elements
which can become toxic at high concentrations and iii) elements that
are intrinsically toxic (Reinhold 1975). Since different organisms have
different nutritional requirements, some elements can be essential for
one organism but toxic to other ones. Calcium, cobalt, chromium (III),
copper, fl uorine, iodine, iron, magnesium, manganese, molybdenum,
potassium, selenium, sodium, and zinc are essential elements. Currently, iron,
zinc, copper, chromium, iodine, cobalt, molybdenum, and selenium are
considered essential for nutrition by the WHO (WHO 2002). Boron, nickel,
silicon, manganese, and vanadium are elements with possible benefi cial effect.
Aluminum, antimony, arsenic, barium, beryllium, cadmium, lead, mercury,

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