Chapter 2
Simultaneous comparisons versus a negative control
2.1 Proof of hazard using simultaneous comparisons versus a negative control
2.1.1 Normally distributed continuous endpoints: The Dunnett procedure
Without any doubt, the Dunnett procedure is one of the most widely used statistical tests in toxicology: 692 of the 3514 citations of the original paper [102] (WebSci January 2014) are applications in toxicology. Moreover, it is recommended by the US NTP [9]. It belongs to multiple comparison procedures which control the familywise error rate. If the control of the familywise error rate is intended, an increase of the false negative rate has to be accepted. This increase can be restricted by i) minimizing the number of simultaneous comparisons, ...
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