Chapter 7

Modeling of dose–response relationships

The majority of approaches in this book are tests on dose-response relationships, such as the Williams trend test. Alternatively, parametric non-linear models for a dose-response relationship can be used. The difference between a qualitative factor dose (assumed in testing) and the quantitative covariate (assumed in modeling) are: i) the relationship between the administered dose and the concentration at the target tissue is commonly unknown, and therefore the less stringent dose level, e.g., zero-dose control and low, medium, high dose may be appropriate, ii) the choice of a particular dose-response model may be more problematic compared with just the assumption of monotonicity when using trend ...

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