2Basics of Experimentation and Response Surface Methodology

“The best time to plan an experiment is after you have done it.”

Sir Ronald A. Fisher

Overview

Our approach to Strategy of Formulation Development relies heavily on the use of response surface methodology. Data is collected using an experimental design from which a model is developed to understand the formulation system and identify formulations that meet the objective of the study. In this chapter we discuss the fundamentals of good experimentation that enable the collection of good data. These fundamentals include well-defined objectives, high quality data, and diagnosis of the experimental environment. We also introduce a roadmap for sequential experimentation and modeling of formulation ...

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