7. Conjunctive Long-Term Depression (LTD)

7-1. Introduction

Among electrical and chemical signaling capabilities of neurons, synaptic plasticity is a unique process that induces persistent changes in synaptic transmission efficacy in an activity-dependent manner. The best-known examples are long-term potentiation (LTP) and depression (LTD). A cascade of cellular/molecular events, which are initiated by an experience, generates these changes. They are considered to culminate in a durable form of altered synaptic transmission efficacy. “Conjunctive LTD,” which is induced postsynaptically by the combined activation of parallel fibers and a climbing fiber converging onto a Purkinje cell, is a unique type of synaptic plasticity in the cerebellum because ...

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