Chapter 6: Lead optimization

Stephanie Kay Ashenden    Data Sciences and Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom


A lead compound has been identified and now must be optimized to become a candidate drug. Lead optimization refers to the process of designing and improving a preidentified lead compound, and involves manipulation of multiple parameters of the compound, relying on chemical modifications to the compound. During this process, synthetic changes are made to optimize the compounds ADMET properties (absorption, distribution, metabolism, excretion, and toxicity) as well as the compound’s activity, potency, and selectivity. In addition, the compound needs to remain novel to allow ...

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