Two-Dimensional (2D) NMR Methods

10 Ultrafast 2D methods

Boris Gouilleux

Université Paris-Saclay, laboratoire ICMMO, ERMN 17 Av. des Sciences, Orsay 91400, France

10.1 Introduction

Much of the power of NMR spectroscopy relies on the ability to correlate information in a multi-dimensional (nD) pattern delivering valuable structural and dynamic insights on the probed compounds. Moreover, the gain in resolution yielded by spreading out the signals over several dimensions makes nD NMR spectroscopy a central method to address analytical challenges such as structural and dynamic studies of large biomolecules or the analysis of smaller compounds within complex matrixes.

The important benefits of the multi-dimensional approach come with a long experimental duration when the 2D spectra are recorded in respect to the conventional scheme introduced by Jeener [1]. In its original form, a 2D interferogram is obtained by performing a series of similar experiments with a linearly incremented -evolution period (Figure 10.1a). This multi-experiment scheme is in essence a time-consuming process, all the more so several scans may be averaged per -increment to complete a phase-cycling or for sensitivity reasons. The overall experiment duration pertained to 2D experiments is expressed by the equation below:

(10.1)

Figure 10.1 (a) ...