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Analysis of Observational Health Care Data Using SAS by Andrew C. Leon, Josep Maria Haro, Robert Obenchain, Douglas E. Faries

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Chapter 15

Incremental Net Benefit

Andrew R. Willan

Abstract

15.1 Introduction

15.2 Cost-Effectiveness Analysis

15.3 Parameter Estimation

15.4 Example

15.5 Observational Studies

15.6 Discussion

Acknowledgments

References

 

Abstract

Since the early 1990s, motivated by the availability of patient-level cost data in clinical studies for comparing patient groups, researchers have made rapid developments in statistical methods for cost-effectiveness data. Initial efforts concentrated on inference about the incremental cost-effectiveness ratio, but due to difficulties associated with ratio statistics, interest has settled more recently on incremental net benefit. Regardless of the approach, five parameters need to be estimated: the between-treatment ...

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