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1 Vaccines: Their place in history
Smallpox in history
Variolation in history
Variolation comes to Britain
Lady Mary Wortley Montagu
Variolation and the Sublime Porte
The royal experiment
The boston connection
Variolation takes hold
The Suttonian method
Variolation in Europe
The coming of vaccination
Vaccination becomes a science
Meister, Pasteur and rabies
A vaccine for every disease
In the time of cholera
Haffkine and cholera
The changing face of disease
Almroth wright and typhoid
Tuberculosis, Koch, and Calmette
Salk and Sabin
Many diseases, many vaccines
2 Vaccines: Need and opportunity
Eradication and reservoirs
The ongoing burden of disease
The evolving nature of disease
Economics, climate and disease
Tuberculosis in the 21st century
HIV and AIDS
Malaria: Then and now
Vaccines as medicines
Vaccines and the pharmaceutical industry
The coming of the vaccine industry
3 Vaccines: How they work
Challenging the immune system
The threat from bacteria: Robust, diverse, and endemic
Microbes, diversity and metagenomics
The intrinsic complexity of the bacterial threat
Microbes and humankind
The nature of vaccines
Types of vaccine
Emerging immunovaccinology ...
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