Chapter 19. The Cochran-Mantel-Haenszel Test
19.1 Introduction 341
19.2 Synopsis 341
19.3 Examples 343
19.4 Details & Notes 355
The Cochran-Mantel-Haenszel test is used in clinical trials to compare two binomial proportions from independent populations based on stratified samples. This test provides a means of combining a number of 2×2 tables of the type discussed in Chapters 16 and 17 when each is from a separate, independent stratum.
The stratification factor can represent patient subgroups, such as study centers, gender, age group, or disease severity, and acts similar to the blocking factor in a two-way ANOVA (Chapter 7). The Cochran-Mantel-Haenszel test obtains an overall comparison of response rates adjusted for the stratification ...