Fundamentals of Systems Biology

Chapter 9Metabolism

Learning Objectives

• Derive the Michaelis–Menten equation for enzyme kinetics
• Adapt the equation to account for inhibitory effects
• Build large-scale metabolic models based on principles of flux balance and linear optimization
• Apply flux balance analysis to predict the metabolic behavior of cells

This is an exciting chapter for me; it not only features some of the most classical and well-established modeling in molecular biology, but also showcases some of the newest and most exciting modeling approaches that played a critical role in building a whole-cell model, as you will see in Chapter 10. The focus is metabolism, specifically carbon and energy metabolism, meaning the processes by which a cell builds all of the molecules ...