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JMP 10 Design of Experiments Guide by SAS Institute

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Chapter 10 
Space-Filling Designs
 
Space-filling designs are useful in situations where run-to-run variability is of far less concern than the form of the model. Sensitivity studies of computer simulations is one such situation. For this case, and any mechanistic or deterministic modeling problem, any variability is small enough to be ignored. For systems with no variability, randomization and blocking are irrelevant. Replication is undesirable because repeating the same run yields the same result. In space-filling designs, there are two objectives:
• Prevent replicate points by spreading the design points out to the maximum distance possible ...

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