April 2025
Intermediate
384 pages
11h 15m
English
Content preview from Machine Learning and AI with Simple Python and Matlab Scripts
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5ANNs for Alzheimer's Disease Prognosis
5.1 Introduction
In this chapter we discuss how machine learning techniques can be exploited for solving otherwise formidable and sometimes intractable problems in life sciences. As a case study, we show how an ANN can be employed for prediction of Alzheimer's disease (AD) prognosis based on personalized biological information. We also present sample Python and Matlab script implementations of such an ANN, trained by field data for biomarkers collected from AD patients over time.
5.2 Alzheimer's Disease
Alzheimer's disease (AD) is an incurable progressive neurodegenerative disorder caused by destruction of neurons within the brain, with typical symptoms of cognitive decline, memory loss, behavioural changes and functional impairment of an individual. As the disease progresses, individuals with AD often experience worsening symptoms and a decline in overall health.
Everyone who develops Alzheimer's dementia first experiences mild cognitive impairment (MCI). Among those with MCI, about 15% develop dementia after two years and approximately one‐third within five years. However, some individuals with MCI do not have additional cognitive decline or revert to normal cognition. Among population‐based studies, a systematic review and meta‐analysis reported a reversion rate of 26% [52]. Therefore, it is vitally important to develop tools to predict whether a patient with MCI will decline (i.e. progressive MCI) or remain stable (i.e. stable MCI). ...
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O’Reilly covers everything we've got, with content to help us build a world-class technology community, upgrade the capabilities and competencies of our teams, and improve overall team performance as well as their engagement.Julian F.
I wanted to learn C and C++, but it didn't click for me until I picked up an O'Reilly book. When I went on the O’Reilly platform, I was astonished to find all the books there, plus live events and sandboxes so you could play around with the technology.Addison B.
I’ve been on the O’Reilly platform for more than eight years. I use a couple of learning platforms, but I'm on O'Reilly more than anybody else. When you're there, you start learning. I'm never disappointed.Amir M.
I'm always learning. So when I got on to O'Reilly, I was like a kid in a candy store. There are playlists. There are answers. There's on-demand training. It's worth its weight in gold, in terms of what it allows me to do.