Molecular Technology, Volume 1

4 Design of Multiproton‐Responsive Metal Complexes as Molecular Technology for Transformation of Small Molecules

Shigeki Kuwata

Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2‐12‐1‐E4‐1 Ookayama, Meguro‐ku, Tokyo, 152‐8552, Japan

4.1 Introduction

The highly efficient and selective catalysis by metalloenzymes in nature relies on the integrated functional groups in their active site. The metal and surrounding peptide residues and other prosthetic groups cooperate in substrate binding, activation, and transformation through multiple weak, noncovalent interactions including hydrogen bonds [1]. Such sophisticated biological catalysis has motivated considerable ...