Strategies for Formulations Development

5Screening Formulation Components

"Look before you leap."

 “The Fox and the Goat,” Aesop's Fables

Overview

In Chapter 2 we introduced the idea of experimental strategy that calls for screening experiments to be run prior to optimization experiments. In this chapter we introduce the screening concepts and designs for formulations. As the Aesop fable suggests, it is important to take a broad view of the possible components before getting into formulation optimization. We discuss screening experiments when the components can be varied over the full range of the components, 0 to 100%. We also discuss screening experiments when the components can be varied over equal ranges. Looking at both approaches enables one to clearly see the concepts and objectives ...