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Analysis of Clinical Trials Using SAS by Geert Molenberghs, Walter W. Offen, Christy Chuang-Stein, Alex Dmitrienko

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Multiple Comparisons and Multiple Endpoints     2

 

 

2.1 Introduction

2.2 Single-Step Tests

2.3 Closed Testing Methods

2.4 Fixed-Sequence Testing Methods

2.5 Resampling-Based Testing Methods

2.6 Testing Procedures for Multiple Endpoints

2.7 Gatekeeping Strategies

This chapter discusses statistical strategies for handling multiplicity issues arising in clinical trials. It covers basic single-step multiple tests and more advanced closed, fixed-sequence and resampling-based multiple testing procedures. The chapter also reviews methods used in the analysis of multiple endpoints and gatekeeping testing strategies for clinical trials with multiple objectives and for dose-finding studies.

2.1 Introduction

Multiplicity problems arise in virtually ...

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