Multiple Comparisons and Multiple Endpoints     2

 

 

2.1 Introduction

2.2 Single-Step Tests

2.3 Closed Testing Methods

2.4 Fixed-Sequence Testing Methods

2.5 Resampling-Based Testing Methods

2.6 Testing Procedures for Multiple Endpoints

2.7 Gatekeeping Strategies

This chapter discusses statistical strategies for handling multiplicity issues arising in clinical trials. It covers basic single-step multiple tests and more advanced closed, fixed-sequence and resampling-based multiple testing procedures. The chapter also reviews methods used in the analysis of multiple endpoints and gatekeeping testing strategies for clinical trials with multiple objectives and for dose-finding studies.

2.1 Introduction

Multiplicity problems arise in virtually ...

Get Analysis of Clinical Trials Using SAS now with the O’Reilly learning platform.

O’Reilly members experience live online training, plus books, videos, and digital content from nearly 200 publishers.