February 2005
Intermediate to advanced
430 pages
15h 6m
English
book
Analysis of Clinical Trials Using SAS
by Alex Dmitrienko, Geert Molenberghs, Christy Chuang-Stein, Walter W. Offen
Content preview from Analysis of Clinical Trials Using SAS
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Multiple Comparisons and Multiple Endpoints 2
2.4 Fixed-Sequence Testing Methods
2.5 Resampling-Based Testing Methods
2.6 Testing Procedures for Multiple Endpoints
This chapter discusses statistical strategies for handling multiplicity issues arising in clinical trials. It covers basic single-step multiple tests and more advanced closed, fixed-sequence and resampling-based multiple testing procedures. The chapter also reviews methods used in the analysis of multiple endpoints and gatekeeping testing strategies for clinical trials with multiple objectives and for dose-finding studies.
2.1 Introduction
Multiplicity problems arise in virtually ...
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