February 2005
Intermediate to advanced
430 pages
15h 6m
English
book
Analysis of Clinical Trials Using SAS
by Alex Dmitrienko, Geert Molenberghs, Christy Chuang-Stein, Walter W. Offen
Content preview from Analysis of Clinical Trials Using SAS
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2.7 Gatekeeping Strategies
This section describes testing procedures for families of hypotheses encountered in clinical trials with hierarchically ordered endpoints and in dose-finding studies. The families are tested in a sequential manner in the sense that the acceptance or rejection of hypotheses in a particular family depends on the outcome of the significance tests carried out in the preceding families. In other words, the families of hypotheses examined earlier serve as gatekeepers , and one can test hypotheses in a particular family only if the preceding gatekeepers have been successfully passed.
Several types of gatekeeping testing procedures for sequential families of hypotheses have been proposed in the literature.
• Bauer et al. ...
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