Complex Networks

Chapter 10

Protein Interaction

Networks

10.1 Introduction

Proteins have important functions in cell biology such as transferring signals, con-

trolling the functions of enzymes and regulating activities in the cell. Proteins interact

with other proteins in the cell to form protein-protein interaction (PPI) networks to

perform important tasks in the cell such as cell cycle control, protein folding, transla-

tion and transcription. A protein may also modify another protein by interacting with

it in a PPI network. Understanding the role of interactions of proteins is believed

to provide molecular indications of health and disease states which can be used ...