Industrial Process Scale-up

Industrial Process Scale-up

by Jan Harmsen
Released April 2013
Publisher(s): Elsevier
ISBN: 9780444627391

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Book description

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses.




    • Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up
    • Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch
    • Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation
    • Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Table of contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. Dedication
  6. Preface
  7. Acknowledgement
  8. Chapter 1. Introduction
    1. 1.1 Purpose of the Book
    2. 1.2 Scale-Up Definition
    3. 1.3 Scale-Up Methodology
    4. 1.4 Content Structure of the Book
  9. Chapter 2. Process Industries Characteristics
    1. 2.1 Industrial Players and Partners
    2. 2.2 Supply and Value Chains
    3. 2.3 Industrial Complexes
    4. 2.4 Processes
    5. 2.5 Unit Operations
    6. 2.6 Major Process Equipment
    7. 2.7 Transfer Phenomena
    8. 2.8 Chemistry and Catalysis
    9. 2.9 Types of Design in Innovation
  10. Chapter 3. Ideation and Research Stages
    1. 3.1 Ideation Stage
    2. 3.2 Research Stage
  11. Chapter 4. Development Stage
    1. 4.1 Mini-Plant Objectives and Design
    2. 4.2 Pilot Plant Objectives and Design
    3. 4.3 Cold-Flow Plant Objectives and Design
    4. 4.4 Commercial Scale Process Design in Development Stage
    5. 4.5 Development Gate Decision
  12. Chapter 5. Demonstration Stage
    1. 5.1 Rationale Demonstration Scale Process
    2. 5.2 Execution Demonstration Stage
  13. Chapter 6. Start-Up Commercial Processes
    1. 6.1 Start-Up Time Prediction
    2. 6.2 Start-Up Organisation
    3. 6.3 Post-Start-Up Reporting
  14. Chapter 7. Scale-Up of Unit Operations
    1. 7.1 Critical Success Factors for Unit Operations and Equipment
    2. 7.2 Scale-Up Methods for Unit Operations
    3. 7.3 Scale-Up of Most Used Unit Operations
  15. Chapter 8. A Risk-Based Approach to Scale-Up of Amine Absorption Processes for CO2 Capture and Storage
    1. 8.1 Introduction
    2. 8.2 Scale-Up of Amine Absorption Processes for CCS
    3. 8.3 Risk-Based Approach to Scale Up of Amine Absorption Processes for CCS
    4. 8.4 Case Study: Applications of the DNV Method to Current Industrial Challenges
    5. 8.5 TQ and Process Development (Scale-Up) Stages
    6. 8.6 Summary
    7. References
  16. Chapter 9. Industrial Scale-Up Cases
    1. 9.1 Liquid–Liquid Extractive Reaction Case
    2. 9.2 Bulk Chemical Product Start-Up Conventional Process
    3. 9.3 Start-Up Conventional Process in South Korea
    4. 9.4 Case Purchasing Novel Process
    5. 9.5 Polymerisation Process Start-Up
    6. 9.6 Styrene Monomer Propylene Oxide Wastewater Novel Design and Implementation
    7. 9.7 Carilon Engineering Polymer Case
    8. 9.8 Purchasing a Commercially Proven Rotating Filter
    9. 9.9 Fermentation Scale-Up
  17. References

Product information

  • Title: Industrial Process Scale-up
  • Author(s): Jan Harmsen
  • Release date: April 2013
  • Publisher(s): Elsevier
  • ISBN: 9780444627391