Chapter 2

Bistability in the Lactose Operon of Escherichia coli: A Comparison of Differential Equation and Boolean Network Models

Raina Robeva* and Necmettin Yildirim, *Department of Mathematical Sciences, Sweet Briar College, Sweet Briar, VA 24595, USA, Division of Natural Sciences, New College of Florida, FL 34243, USA

2.1 Introduction

Cellular systems are complex and involve many interacting components, which are ultimately responsible for cellular functions. Such complexity is capable of producing interesting dynamic behaviors. Among such behaviors, bistability is extremely important and is a recurring pattern in biological systems. A system is called bistable if it is capable of resting in two stable steady states separated by an unstable ...

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