Real World Health Care Data Analysis

Chapter 12: A Target Trial Approach with Dynamic Treatment Regimes and Replicates Analyses

12.1 Introduction

12.2 Dynamic Treatment Regimes and Target Trial Emulation

12.2.1 Dynamic Treatment Regimes

12.2.2 Target Trial Emulation

12.3 Example: Target Trial Approach Applied to the Simulated REFLECTIONS Data

12.3.1 Study Question

12.3.2 Study Description and Data Overview

12.3.3 Target Trial Study Protocol

12.3.4 Generating New Data

12.3.5 Creating Weights

12.3.6 Base-Case Analysis

12.3.7 Selecting the Optimal Strategy

12.3.8 Sensitivity Analyses

12.4 Summary

References

12.1 Introduction

The comparative effectiveness of dynamic treatment regimes is often assessed based on observational longitudinal data. Dynamic treatment regimes are different ...