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Temperature-Responsive Polymers
book

Temperature-Responsive Polymers

by Vitaliy V. Khutoryanskiy, Theoni K. Georgiou
August 2018
Intermediate to advanced content levelIntermediate to advanced
408 pages
15h 32m
English
Wiley
Content preview from Temperature-Responsive Polymers

Chapter 12Temperature‐responsive Polymers for Tissue Engineering

Kenichi Nagase1,2 Masayuki Yamato1, and Teruo Okano1

1Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Shinjuku, Tokyo, 162‐8666, Japan

2Faculty of Pharmacy, Keio University, Minato, Tokyo 105‐8512, Japan

12.1 Introduction

Temperature‐responsive polymers are widely used in various biomedical applications. This chapter introduces thermo‐responsive polymers for tissue engineering. In particular, one of the most successful applications is the thermo‐responsive cell culture dishes for fabrication of “cell sheets.” Many types of cell sheets are currently needed for medical treatments, and others will be needed in the future [17]. Various modification techniques for thermo‐responsive polymers have been investigated for highly efficient cell culture dishes. In this chapter, progress in this important area is summarized.

12.1.1 Thermo‐responsive Cell Culture Dishes and Cell Sheets

The thermo‐responsive polymer poly(N‐isopropylacrylamide) (PIPAAm) is widely used in biomedical applications because it switches between hydrophilic and hydrophobic states at the lower critical solution temperature of 32 °C, which is near body temperature. The temperature‐dependent hydrophilic/hydrophobic transition of PIPAAm‐modified surfaces has been used for cell adhesion and detachment. This is shown schematically in Figure 12.1a for a PIPAAm hydrogel‐modified substrate. Cells adhere to the surface ...

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Publisher Resources

ISBN: 9781119157786