Chapter 12Temperature‐responsive Polymers for Tissue Engineering
Kenichi Nagase1,2 Masayuki Yamato1, and Teruo Okano1
1Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Shinjuku, Tokyo, 162‐8666, Japan
2Faculty of Pharmacy, Keio University, Minato, Tokyo 105‐8512, Japan
12.1 Introduction
Temperature‐responsive polymers are widely used in various biomedical applications. This chapter introduces thermo‐responsive polymers for tissue engineering. In particular, one of the most successful applications is the thermo‐responsive cell culture dishes for fabrication of “cell sheets.” Many types of cell sheets are currently needed for medical treatments, and others will be needed in the future [1–7]. Various modification techniques for thermo‐responsive polymers have been investigated for highly efficient cell culture dishes. In this chapter, progress in this important area is summarized.
12.1.1 Thermo‐responsive Cell Culture Dishes and Cell Sheets
The thermo‐responsive polymer poly(N‐isopropylacrylamide) (PIPAAm) is widely used in biomedical applications because it switches between hydrophilic and hydrophobic states at the lower critical solution temperature of 32 °C, which is near body temperature. The temperature‐dependent hydrophilic/hydrophobic transition of PIPAAm‐modified surfaces has been used for cell adhesion and detachment. This is shown schematically in Figure 12.1a for a PIPAAm hydrogel‐modified substrate. Cells adhere to the surface ...
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