March 2023
Intermediate to advanced
448 pages
12h 40m
English
book
Bioinformatics Tools for Pharmaceutical Drug Product Development
by Vivek Chavda, Krishnan Anand, Vasso Apostolopoulos
Content preview from Bioinformatics Tools for Pharmaceutical Drug Product Development
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5Mass Spectrometry, Protein Interaction and Amalgamation of Bioinformatics
Vivek Chavda1, Kaustubh Dange2* and Madhav Joglekar3
1Department of Pharmaceutic and Pharmaceutical Technology, L M College of Pharmacy, Ahmedabad, India
2Product Characterization Team, Lupin Ltd., Pune, Maharashtra, India
3Analytical Development Team, Lupin Ltd., Pune, Maharashtra, India
Abstract
Mass spectrometry (MS) is the major and favorable analytical tool for the dynamic ‘‘-omics’’ technologies. It facilitates detection of thousands of proteins with its quantitation. Also, biologically active metabolites and body fluid can be analyzed in global as well as targeted way, at very trace amount level. With recent advances in MS technologies and sample handling strategies it is even possible to analyze single cells. With all advances in MS technology and Sample handling strategies, data interpretation part is still a challenging subject which are interdisciplinary, the notable domain-specific knowledge as well as sound knowledge about software platforms and mechanism behind the MS platform are needed for correct and optimal processing of data.
Keywords: Mass spectrometry, bioinformatics, protein interaction, proteomics, omics technology
5.1 Introduction
Mass spectrometry is a sensitive analytical technique in which molecule gets detected, identified and quantitated on basis of ratio of mass of ion to its charge. The development of high-throughput and quantitative MS proteomics workflows in recent ...
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