Fundamentals of Systems Biology

Book description

For decades biology has focused on decoding cellular processes one gene at a time, but many of the most pressing biological questions, as well as diseases such as cancer and heart disease, are related to complex systems involving the interaction of hundreds, or even thousands, of gene products and other factors. How do we begin to understand this complexity?

Fundamentals of Systems Biology: From Synthetic Circuits to Whole-cell Models introduces students to methods they can use to tackle complex systems head-on, carefully walking them through studies that comprise the foundation and frontier of systems biology. The first section of the book focuses on bringing students quickly up to speed with a variety of modeling methods in the context of a synthetic biological circuit. This innovative approach builds intuition about the strengths and weaknesses of each method and becomes critical in the book’s second half, where much more complicated network models are addressed—including transcriptional, signaling, metabolic, and even integrated multi-network models.

The approach makes the work much more accessible to novices (undergraduates, medical students, and biologists new to mathematical modeling) while still having much to offer experienced modelers--whether their interests are microbes, organs, whole organisms, diseases, synthetic biology, or just about any field that investigates living systems.

Table of contents

  1. Front Cover (1/2)
  2. Front Cover (2/2)
  3. Contents (1/2)
  4. Contents (2/2)
  5. Preface (1/2)
  6. Preface (2/2)
  7. Acknowledgments
  8. About the Author
  9. Chapter 1: Variations on a Theme of Control (1/2)
  10. Chapter 1: Variations on a Theme of Control (2/2)
  11. Chapter 2: Variation: Boolean Representations (1/5)
  12. Chapter 2: Variation: Boolean Representations (2/5)
  13. Chapter 2: Variation: Boolean Representations (3/5)
  14. Chapter 2: Variation: Boolean Representations (4/5)
  15. Chapter 2: Variation: Boolean Representations (5/5)
  16. Chapter 3: Variation: Analytical Solutions of Ordinary Differential Equations (1/6)
  17. Chapter 3: Variation: Analytical Solutions of Ordinary Differential Equations (2/6)
  18. Chapter 3: Variation: Analytical Solutions of Ordinary Differential Equations (3/6)
  19. Chapter 3: Variation: Analytical Solutions of Ordinary Differential Equations (4/6)
  20. Chapter 3: Variation: Analytical Solutions of Ordinary Differential Equations (5/6)
  21. Chapter 3: Variation: Analytical Solutions of Ordinary Differential Equations (6/6)
  22. Chapter 4: Variation: Graphical Analysis (1/6)
  23. Chapter 4: Variation: Graphical Analysis (2/6)
  24. Chapter 4: Variation: Graphical Analysis (3/6)
  25. Chapter 4: Variation: Graphical Analysis (4/6)
  26. Chapter 4: Variation: Graphical Analysis (5/6)
  27. Chapter 4: Variation: Graphical Analysis (6/6)
  28. Chapter 5: Variation: Numerical Integration (1/4)
  29. Chapter 5: Variation: Numerical Integration (2/4)
  30. Chapter 5: Variation: Numerical Integration (3/4)
  31. Chapter 5: Variation: Numerical Integration (4/4)
  32. Chapter 6: Variation: Stochastic Simulation (1/7)
  33. Chapter 6: Variation: Stochastic Simulation (2/7)
  34. Chapter 6: Variation: Stochastic Simulation (3/7)
  35. Chapter 6: Variation: Stochastic Simulation (4/7)
  36. Chapter 6: Variation: Stochastic Simulation (5/7)
  37. Chapter 6: Variation: Stochastic Simulation (6/7)
  38. Chapter 6: Variation: Stochastic Simulation (7/7)
  39. Chapter 7: Transcriptional Regulation (1/8)
  40. Chapter 7: Transcriptional Regulation (2/8)
  41. Chapter 7: Transcriptional Regulation (3/8)
  42. Chapter 7: Transcriptional Regulation (4/8)
  43. Chapter 7: Transcriptional Regulation (5/8)
  44. Chapter 7: Transcriptional Regulation (6/8)
  45. Chapter 7: Transcriptional Regulation (7/8)
  46. Chapter 7: Transcriptional Regulation (8/8)
  47. Chapter 8: Signal Transduction (1/11)
  48. Chapter 8: Signal Transduction (2/11)
  49. Chapter 8: Signal Transduction (3/11)
  50. Chapter 8: Signal Transduction (4/11)
  51. Chapter 8: Signal Transduction (5/11)
  52. Chapter 8: Signal Transduction (6/11)
  53. Chapter 8: Signal Transduction (7/11)
  54. Chapter 8: Signal Transduction (8/11)
  55. Chapter 8: Signal Transduction (9/11)
  56. Chapter 8: Signal Transduction (10/11)
  57. Chapter 8: Signal Transduction (11/11)
  58. Chapter 9: Metabolism (1/13)
  59. Chapter 9: Metabolism (2/13)
  60. Chapter 9: Metabolism (3/13)
  61. Chapter 9: Metabolism (4/13)
  62. Chapter 9: Metabolism (5/13)
  63. Chapter 9: Metabolism (6/13)
  64. Chapter 9: Metabolism (7/13)
  65. Chapter 9: Metabolism (8/13)
  66. Chapter 9: Metabolism (9/13)
  67. Chapter 9: Metabolism (10/13)
  68. Chapter 9: Metabolism (11/13)
  69. Chapter 9: Metabolism (12/13)
  70. Chapter 9: Metabolism (13/13)
  71. Chapter 10: Integrated Models (1/6)
  72. Chapter 10: Integrated Models (2/6)
  73. Chapter 10: Integrated Models (3/6)
  74. Chapter 10: Integrated Models (4/6)
  75. Chapter 10: Integrated Models (5/6)
  76. Chapter 10: Integrated Models (6/6)
  77. Glossary (1/2)
  78. Glossary (2/2)
  79. Back Cover

Product information

  • Title: Fundamentals of Systems Biology
  • Author(s): Markus W. Covert
  • Release date: February 2015
  • Publisher(s): CRC Press
  • ISBN: 9781498728478