Mendelian Randomization, 2nd Edition

9

Extensions to Mendelian randomization

In this chapter, we consider extensions to the basic Mendelian randomization paradigm. These include approaches with multiple exposure variables and those which aim to estimate a parameter other than that estimated in a standard Mendelian randomization investigation. We consider in turn multivariable Mendelian randomization, network Mendelian randomization, non-linear Mendelian randomization, factorial Mendelian randomization, bidirectional Mendelian randomization, and meta-analysis in Mendelian randomization.

9.1 Multivariable Mendelian randomization

Multivariable Mendelian randomization [Burgess and Thompson, 2015] is an extension to standard Mendelian randomization that can be used when it ...