February 2005
Intermediate to advanced
430 pages
15h 6m
English
book
Analysis of Clinical Trials Using SAS
by Alex Dmitrienko, Geert Molenberghs, Christy Chuang-Stein, Walter W. Offen
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Interim Data Monitoring 4
4.2 Repeated Significance Tests
4.3 Stochastic Curtailment Tests
This chapter reviews sequential data monitoring strategies in clinical trials. It introduces a class of group sequential tests (known as repeated significance tests) that are widely used in the assessment of interim findings in clinical applications. The first part of the chapter provides a detailed review of the process of designing group sequential trials and also discusses flexible procedures for monitoring clinical trial data. The second part of the chapter reviews popular approaches to constructing futility-testing procedures in clinical trials. These approaches are based on frequentist (conditional power), mixed Bayesian-frequentist ...
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O’Reilly covers everything we've got, with content to help us build a world-class technology community, upgrade the capabilities and competencies of our teams, and improve overall team performance as well as their engagement.Julian F.
I wanted to learn C and C++, but it didn't click for me until I picked up an O'Reilly book. When I went on the O’Reilly platform, I was astonished to find all the books there, plus live events and sandboxes so you could play around with the technology.Addison B.
I’ve been on the O’Reilly platform for more than eight years. I use a couple of learning platforms, but I'm on O'Reilly more than anybody else. When you're there, you start learning. I'm never disappointed.Amir M.
I'm always learning. So when I got on to O'Reilly, I was like a kid in a candy store. There are playlists. There are answers. There's on-demand training. It's worth its weight in gold, in terms of what it allows me to do.