Cancer Biology by Pearson

Cancer Biology by Pearson

by V. Deepa Parvathi
Released December 2023
Publisher(s): Pearson India
ISBN: 9789357054522

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Book description

This book on Cancer Biology is structured to build basic concepts in Neoplasia. Spread across seven chapters, the book provides a detailed description of the basics of cancer along with the molecular machinery, etiology and pathogenesis, cell signalling, hallmarks of cancer, cancer stem cells, animal models used for research,novel therapeutic approaches, case studies, clinical trials, and counselling. Additionally, review questions have been included to help the leaners reflect their understanding.

Table of contents

  1. Cover
  2. About Pearson
  3. Title Page
  4. Dedication
  5. Contents
  6. Foreword
  7. Preface
  8. Acknowledgements
  9. About the Authors
  10. Chapter 1: Cancer: An Introduction
    1. 1.1 What is Cancer?
    2. 1.2 Origin of Cancer
    3. 1.3 Genetics of Cancer
    4. 1.4 Types of Cancer
      1. 1.4.1 Carcinoma
      2. 1.4.2 Sarcoma
      3. 1.4.3 Lymphoma
      4. 1.4.4 Blastoma
      5. 1.4.5 Leukemia
      6. 1.4.6 Multiple Myeloma
    5. 1.5 Neoplastic Characteristics
    6. 1.6 A Note on Oncology
      1. 1.6.1 Role of an Oncologist
    7. 1.7 Role of the National Cancer Institute (NCI)
      1. 1.7.1 Cancer Research
      2. 1.7.2 Training and Support for Cancer Researchers
  11. Chapter 2: Generation of Cancer
    1. 2.1 Theories of Carcinogenesis
      1. 2.1.1 Mechanisms of Carcinogenesis
    2. 2.2 Tumour Morphology
      1. 2.2.1 Properties of Tumours
    3. 2.3 Metastasis
    4. 2.4 Tumour Markers
    5. 2.5 Cancer Stem Cells
    6. 2.6 Animal Models Used for Cancer Research
      1. 2.6.1 Use of Cancer Cell Lines in Research
    7. Suggested Reading
  12. Chapter 3: General Etiology and Pathogenesis
    1. 3.1 Genes Involved
      1. 3.1.1 Proto-oncogenes
      2. 3.1.2 Oncogenes
      3. 3.1.3 Tumor Suppressor Genes
      4. 3.1.4 DNA Repair Genes
    2. 3.2 Types of Mutations
      1. 3.2.1 Somatic or Sporadic Mutations
      2. 3.2.2 Germline Mutations
    3. 3.3 Telomerase Activity and Cancer Cells
    4. 3.4 Apoptosis and Cancer Cells
      1. 3.4.1 Bcl-2 Family of Proteins
      2. 3.4.2 p53
      3. 3.4.3 Inhibitor of Apoptosis Proteins (IAPs)
      4. 3.4.4 Decreased Activity of Caspases
      5. 3.4.5 Impairment in Death Receptor Signaling
    5. 3.5 Chromosomal Defects
    6. 3.6 Epigenetic Aberrations in Cancer
    7. 3.7 Identification of Hereditary Cancer
    8. 3.8 Hereditary Cancer Syndromes
    9. 3.9 Non-Hereditary Cancer Syndromes
    10. 3.10 Familial Cancer Syndromes
    11. 3.11 Genetic and Environmental Interactions That Lead to Cancer
    12. 3.12 Genetics Tests to Identify Cancer
  13. Chapter 4: Cell Cycle and Cell Signaling
    1. 4.1 Cell Cycle
      1. 4.1.1 Cell Cycle Checkpoints (G1 Checkpoint, G2 Checkpoint and Spindle Checkpoint)
      2. 4.1.2 Cell Cycle Regulators (Cyclins, Cyclin Dependent Kinases, Maturation Promoting Factor, Anaphase Promoting Factor/Cyclosome, P53 and CDK Inhibitors)
    2. 4.2 Regulation at the Interphase
    3. 4.3 Events That Lead to Deregulation of Cell Cycle
    4. 4.4 Mutations in Genes (Oncogenes and Tumor Suppressor Genes)
    5. 4.5 Faulty DNA Repair Mechanism
    6. 4.6 Programmed Cell Death – Apoptosis
    7. 4.7 Dysregulation in Cell Signaling Pathways Leading to Cancer
      1. 4.7.1 Akt/PKB Signaling
      2. 4.7.2 The AMP-activated Protein Kinase (AMPK) Signaling
      3. 4.7.3 cAMP-dependent Signaling
      4. 4.7.4 Eph/Ephrin Signaling Pathway
      5. 4.7.5 Hedgehog Signaling Pathway
      6. 4.7.6 Hippo Signaling Pathway
      7. 4.7.7 JAK-STAT Signaling Pathway
      8. 4.7.8 MAPK/ERK Signaling Pathway
      9. 4.7.9 mTOR Signaling Pathway
      10. 4.7.10 Nodal Signaling Pathway
      11. 4.7.11 Notch Signaling Pathway
      12. 4.7.12 PI3K/AKT/mTOR Signaling Pathway
      13. 4.7.13 TGF Beta Signaling Pathway
      14. 4.7.14 TLR Signaling Pathway
      15. 4.7.15 VEGF Signaling Pathway
      16. 4.7.16 Wnt Signaling Pathway
    8. Suggested Reading
  14. Chapter 5: Hallmarks of Cancer
    1. 5.1 Introduction
    2. 5.2 Hallmarks of Cancer
      1. 5.2.1 Avoiding Immune Destruction
      2. 5.2.2 Resistance to Apoptosis-mediated Cell Death
      3. 5.2.3 Dysregulation of Cellular Energetics
      4. 5.2.4 Sustenance of Proliferative Signalling
      5. 5.2.5 Evasion of Growth Suppressors
      6. 5.2.6 Replicative Immortality
      7. 5.2.7 Invasion and Subsequent Metastasis
      8. 5.2.8 Sustained Angiogenesis
      9. 5.2.9 Genomic Instability and Mutation
      10. 5.2.10 Tumour-mediated Inflammatory Response
  15. Chapter 6: Treatment and Other Novel Therapeutic Approaches
    1. 6.1 Principles of Cancer Surgery
      1. 6.1.1 Aim of Surgical Resection
      2. 6.1.2 Factors Affecting Cancer Surgery
      3. 6.1.3 Categories of Cancer Surgery
      4. 6.1.4 Specialised Cancer Surgery
    2. 6.2 Principles of Chemotherapy
      1. 6.2.1 Types of Chemotherapy
      2. 6.2.2 Treatment Strategy
      3. 6.2.3 General Mechanism of Action
      4. 6.2.4 Log Kill Phenomenon
      5. 6.2.5 Indications of Chemotherapy
      6. 6.2.6 Sensitivity to Chemotherapy
      7. 6.2.7 Cell Cycle Specific Drugs
      8. 6.2.8 Limitations Associated with Chemotherapy
    3. 6.3 Radiation Therapy
      1. 6.3.1 General Mechanism of Action
      2. 6.3.2 Treatment Planning and Delivery
      3. 6.3.3 Indications of Radiation Therapy
      4. 6.3.4 Types of Radiation Therapy
      5. 6.3.5 Chemoradiation
      6. 6.3.6 Side Effects
    4. 6.4 Immunotherapy
      1. 6.4.1 Tumor-Infiltrating Lymphocytes
      2. 6.4.2 Monoclonal Antibodies
      3. 6.4.3 Cytokine Therapy
      4. 6.4.4 Immmune Checkpoint Inhibitors
      5. 6.4.5 Vaccine Therapy
    5. 6.5 Targeted Therapy
      1. 6.5.1 General Mechanism of Action
      2. 6.5.2 Drugs Used for Targeted Therapy
      3. 6.5.3 Identification of Cancer Molecular Targets
      4. 6.5.4 Types of Targeted Therapies
      5. 6.5.5 Types of Nano-drug Carriers
    6. 6.6 Hormone Therapy
    7. 6.7 Stem Cell Transplant
      1. 6.7.1 Types of Stem Cell Used in Cancer Therapy
      2. 6.7.2 Potential Application
      3. 6.7.3 Associated Risks and Side Effects
    8. 6.8 Precision Medicine
      1. 6.8.1 Next Generation DNA Sequencing (NGS)
    9. 6.9 Drug Screening
    10. 6.10 Cryoablation
    11. 6.11 Radiofrequency Ablation
    12. 6.12 CAR-T Cell Therapy
      1. 6.12.1 Structure of CAR T-Cells
    13. 6.13 CRISPR
      1. 6.13.1 Indications of CRISPR for Cancer Therapy
      2. 6.13.2 Limitations
    14. 6.14 Adoptive Cell Therapy
      1. 6.14.1 ACT Using Tumour Infiltrating Lymphocytes (TILs)
      2. 6.14.2 Enhancing the Effectiveness of ACT
    15. 6.15 Gene Therapy and Exome Editing
      1. 6.15.1 General Mechanism of Action
      2. 6.15.2 Advantages of Gene Therapy
      3. 6.15.3 Efficiency of Gene Therapy as Cancer Treatment
      4. 6.15.4 Delivery Vectors for Cancer Gene Therapy
    16. 6.16 Clinical Trials
    17. 6.17 Conclusion
    18. Suggested Reading
  16. Chapter 7: Diagnosis, Prognosis and Counseling
    1. 7.1 Molecular Profiling of Cancer
      1. 7.1.1 Genetics of Cancer
      2. 7.1.2 Comparative Genome Hybridization (CGH)
      3. 7.1.3 Chromosome Microarray
      4. 7.1.4 Gene Expression Testing
      5. 7.1.5 Fluorescence in situ Hybridisation - Chronic Myeloid Leukaemia as an Example
      6. 7.1.6 Next Generation Sequencing (NGS)
      7. 7.1.7 Whole Exome Sequencing (WES)
      8. 7.1.8 Whole Genome Sequencing (WGS)
    2. 7.2 Diagnosis of Cancer
      1. 7.2.1 Physical Exam
      2. 7.2.2 Laboratory Tests
      3. 7.2.3 Imaging Tests
      4. 7.2.4 Biopsy
    3. 7.3 Goals of Cancer Treatment
      1. 7.3.1 Cure
      2. 7.3.2 Primary Treatment
      3. 7.3.3 Adjuvant Treatment
      4. 7.3.4 Palliative Treatment
    4. 7.4 Prognosis
      1. 7.4.1 Factors Affecting Cancer Prognosis
      2. 7.4.2 Information Regarding Cancer Prognosis – Personal Choice
      3. 7.4.3 TNM System of Cancer Staging
      4. 7.4.4 Statistics to Estimate Prognosis
    5. 7.5 Genetic Counselling in Cancer
    6. Suggested Reading
  17. Summary
  18. Frequently Asked Questions
  19. Glossary
  20. Index
  21. Copyright

Product information

  • Title: Cancer Biology by Pearson
  • Author(s): V. Deepa Parvathi
  • Release date: December 2023
  • Publisher(s): Pearson India
  • ISBN: 9789357054522