
70 • Julia Zhang
At the same time, the biopharmaceutical industry, private and public
institutions, and government have invested heavily in a large number of
research platforms and more research-specic initiatives than are prac-
tical to mention. It should be the best of times for drug development,
but, alas, it is the worst of times. Despite increasing nancial investment
in pharmaceutical R&D (research and development), innovation has
reached a plateau. is has been exacerbated by patent expirations, poor
outcomes from R&D, increasing regulatory burden around the globe,
and healthcare reimbursement issues. Figure4.2 shows a model of dr