Chapter 9. The Crossover Design
9.1 Introduction 171
9.2 Synopsis 172
9.3 Examples 174
9.4 Details & Notes 185
9.1 Introduction
The crossover design is used to compare the mean responses of two or more treatments when each patient receives each treatment over successive time periods. Typically, patients are randomized to treatment sequence groups which determine the order of treatment administration.
While responses among treatments in a parallel study are considered independent, responses among treatments in a crossover study are correlated because they are measured on the same patient, much like the repeated measures setup discussed in Chapter 8. In fact, the crossover is a special case of a repeated measures design. Procedures for treatment comparisons ...
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