366
(AngII) by inhibiting angiotensin converting enzyme, and AngII can increase the expression
of pro-apoptotic gene Bax and decrease the expression of anti-apoptotic genes Bcl-2, that is,
leading to the reduction in the ratio of Bcl-2/Bax to induce the apoptosis (Zhou et al. 2009),
captopril, on the one hand, may play an inhibitory effect on the apoptosis by blocking the
formation of AngII, on the other hand, captopril can also inhibit associated genes that can
mediate the myocardial hypertrophy by antagonizing the up-regulated expression of IL-6
family cytokines (CT-1, LIF, IL-6) mediated by angiotensin II and indirectly by inhibiting the
expression their receptor gpl30, thereby to inhibit the JAK/STAT3 signaling pathway, delay-
ing the ventricular ...