Book description
Contemporary biomedical and clinical research is undergoing constant development thanks to the rapid advancement of various high throughput technologies at the DNA, RNA and protein levels. These technologies can generate vast amounts of raw data, making bioinformatics methodologies essential in their use for basic biomedical and clinical applications.Bioinformatics for biomedical science and clinical applications demonstrates what these cutting-edge technologies can do and examines how to design an appropriate study, including how to deal with data and address specific clinical questions. The first two chapters consider Bioinformatics and analysis of the human genome. The subsequent three chapters cover the introduction of Transcriptomics, Proteomics and Systems biomedical science. The remaining chapters move on to critical developments, clinical information and conclude with domain knowledge and adaptivity.
- A coherent presentation of concepts, methodologies and practical tools that systematically lead to significant discoveries in the biomedical and clinical area
- Real examples of cutting edge discoveries
- The introduction of study types and technologies for all the DNA, RNA and protein levels
Table of contents
- Cover image
- Title page
- Table of Contents
- Copyright
- List of figures and tables
- Preface
- About the author
- Chapter 1: Introduction
-
Chapter 2: Genomics
- Abstract:
- 2.1 Introduction
- 2.2 The human genome and variome
- 2.3 Genomic platforms and platform level analysis
- 2.4 Study designs and contrast level analysis of GWAS
- 2.5 Adaptive exploration of interactions of multiple genes
- 2.6 Somatic genomic alterations and cancer
- 2.7 Case studies
- 2.8 Take home messages
-
Chapter 3: Transcriptomics
- Abstract:
- 3.1 Introduction
- 3.2 Transcriptomic platforms at a glance
- 3.3 Platform level analysis for transcriptomics
- 3.4 Contrast level analysis and global visualization
- 3.5 Module level analysis
- 3.6 Systems level analysis for causal inference
- 3.7 RNA secondary structure analysis
- 3.8 Case studies
- 3.9 Take home messages
- Chapter 4: Proteomics
- Chapter 5: Systems biomedical science
- Chapter 6: Clinical developments
- Chapter 7: Conclusions
- Index
Product information
- Title: Bioinformatics for Biomedical Science and Clinical Applications
- Author(s):
- Release date: July 2013
- Publisher(s): Woodhead Publishing
- ISBN: 9781908818232
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