Design & Analysis of Clinical Trials for Economic Evaluation & Reimbursement

45Health Economic Evaluation Concepts

predict the proportion of patients alive after 4years or even to estimate the

survival probabilities from elsewhere (e.g. from published life tables).

The type of statistical model which involves the use of patient-level data may

not be possible for some types of health economic evaluation models, often

because patient-level data is not always available. Aggregate data (e.g. sum-

marised/synthesised from clinical trial reports or publications) form a basis for

populating some health economic evaluation models. For example, the propor-

tion alive 5 years after taking a new treatment might be calculated in several

ways. One way is by taking the average (mean) of 5 year survival rates reported

across several ...