Design & Analysis of Clinical Trials for Economic Evaluation & Reimbursement

127Quality of Life in Economic Evaluation

5.5 HRQoL Metrics for Use in Economic Evaluations

One key aspect of an economic evaluation is the derivation of the metric (or

input) for generating the ICER and the cost-effectiveness acceptability curve

(CEAC). There are two common metrics derived from raw HRQoL data used

in an economic evaluation. These are

1. The QALY

2. The Q-TWiST

Both of these measures have relative advantages and disadvantages, which

have been discussed extensively, particularly the QALY (Culyer et al., 2011).

Not all may be accepted by every reimbursement authority, because some

authorities (e.g. in Germany) prefer to consi ...