Design & Analysis of Clinical Trials for Economic Evaluation & Reimbursement

50 Design & Analysis of Clinical Trials for Economic Evaluation

set lsmqaly;

run;

proc transpose data=lsmqaly2 out=lsmqaly3;

by bootno;

id trt;

var estimate;

run;

data bootdiffqaly;

set lsmqaly3;

incr_qaly_boot=a-b;**get mean incremental effects**;

run;

**merge bootstrap costs and qalys**;

data boot_all1;

merge bootdiffqaly bootdiffcosts;

by bootno;

icer=incr_costs_boot/incr_qaly_boot;**compute ICER**;

run;

**Sort ICER in order**;

proc sort data=boot_all1;

by icer;

run;

**statistics**;

proc univariate data=boot_all1;

var icer;

output out=final pctlpts=2.5, 97.5 pctlpre=ci;

run;

2A.2 STATA Command for Bootstrap

The STATA command for Bootstrap can also be accessed via http://www.

uphs.upenn.edu/dgimhsr/stat-cicer.htm.

First compute the NMB for each treatment. Assign a variable ...