November 2015
Intermediate to advanced
339 pages
10h 38m
English
Content preview from Design & Analysis of Clinical Trials for Economic Evaluation & Reimbursement
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132 Design & Analysis of Clinical Trials for Economic Evaluation
predicted EQ-5D estimates at 4 months and all subsequent months
should be equal to zero. A model could have been used to incorporate
the censoring feature into QoL data, but this complicates the model con-
siderably. The simple option is to set all EQ-5D values to 0 after death
(which may also have implications for the correlations between EQ-5D
over time).
For this example, the Kaplan–Meier survival times up to 2 years for
Treatment A are as shown in Table5.3 with predicted EQ-5D.
The expected (i.e. mean) QALY (or quality-adjusted survival [QAS]) is
given by
QALY = Σ EQ − 5D
i
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