November 2015
Intermediate to advanced
339 pages
10h 38m
English
Content preview from Design & Analysis of Clinical Trials for Economic Evaluation & Reimbursement
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147Quality of Life in Economic Evaluation
This form of the model is not useful for modelling and requires re-
parameterisation so that the mean and variance can be modelled as func-
tions of the predictors. The mean and variance of a beta (α,β) function are α/
(α+β) and αβ/(α+β)
2
(α+β+1), where α and β are the shape and scale parameters,
respectively. Previously, the BB regression approach has been used in an
attempt to model the shape parameters and not the simpler transformation
of the shape parameters in terms of the mean and precision.
By specifying two link functions, from the mean and precision
parameters – h(μ)=logit (μ) for the mean; g( ...
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