June 2023
Intermediate to advanced
460 pages
6h 20m
Japanese
Content preview from Pythonではじめるバイオインフォマティクス ―可読性・拡張性・再現性のあるコードを書くために
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13章
制限部位：使い方、テスト、コードの共有
DNA上の回文配列とは、5’から3’の塩基対の配列が両鎖で同一であるものを指します。例えば、図13-1は、DNA配列GCATGCの逆相補が配列そのものであることを示しています。
図13-1 回文配列はその逆相補配列と同一である
これを確認するコードは以下になります。
>>> from Bio import Seq>>> seq = 'GCATGC'>>> Seq.reverse_complement(seq) == seqTrue
Rosalind REVPチャレンジ（https://oreil.ly/w3Tdm）に記載の通り、制限酵素は制限部位と呼ばれるDNAの特定の回文配列を認識し切断します。制限酵素の長さは通常4から12ヌクレオチドです。本演習の目標はすべての推定された制限酵素のDNA配列中の位置を見つけることです。本課題を解決するためのコードは非常に複雑になりがちです。しかし、関数型プログラミングのテクニックを理解することで、簡潔でエレガントな解法を導き出せます。ここでは、map()、zip()、enumerate()や、多くの関数について説明していきます。
この章では、以下のことを学びます。
- 回文配列の見つけ方
- 共通した機能を共有するためのモジュールの作成方法
- 環境変数
PYTHONPATHについて
13.1 はじめましょう
本演習のコードとテストは13_revpディレクトリにあります。解法をプログラム
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I'm always learning. So when I got on to O'Reilly, I was like a kid in a candy store. There are playlists. There are answers. There's on-demand training. It's worth its weight in gold, in terms of what it allows me to do.